Contradiction with Genesis 1:28
Genesis 25:11 talks about God blessing Isaac after Abraham's death, whereas Genesis 1:28 refers to God's blessing to humanity to be fruitful and multiply; the former is specific to one individual, the latter to all humanity.
Genesis 1:28: And God blessed them, and God said unto them, Be fruitful, and multiply, and replenish the earth, and subdue it: and have dominion over the fish of the sea, and over the fowl of the air, and over every living thing that moveth upon the earth. [moveth: Heb. creepeth]
Contradiction with Exodus 20:12
Genesis 25:11 describes God blessing Isaac post-Abraham's death, focusing on God's direct blessing, whereas Exodus 20:12 instructs the blessing of those who honor their parents while they are alive, emphasizing human action.
Exodus 20:12: Honour thy father and thy mother: that thy days may be long upon the land which the LORD thy God giveth thee.
Contradiction with Hebrews 11:9
Genesis 25:11 mentions God's blessing to Isaac in the land of Beer-lahai-roi, but Hebrews 11:9 speaks to living as strangers in a foreign land by faith, not receiving tangible blessings.
Hebrews 11:9: By faith he sojourned in the land of promise, as [in] a strange country, dwelling in tabernacles with Isaac and Jacob, the heirs with him of the same promise: