Contradiction with John 14:6
Isaiah 45:22 directs all to look unto God for salvation, while John 14:6 states that salvation is through Jesus Christ alone.
John 14:6: Jesus saith unto him, I am the way, the truth, and the life: no man cometh unto the Father, but by me.
Contradiction with Acts 4:12
Isaiah 45:22 suggests turning to God for salvation, whereas Acts 4:12 claims there is no salvation outside of Jesus Christ.
Acts 4:12: Neither is there salvation in any other: for there is none other name under heaven given among men, whereby we must be saved.
Contradiction with 1 Timothy 2:5
Isaiah 45:22 implies direct access to God for salvation, while 1 Timothy 2:5 emphasizes that there is one mediator between God and humans, Jesus.
1 Timothy 2:5: For [there is] one God, and one mediator between God and men, the man Christ Jesus;