Contradiction with Genesis 13:16
God's promise to Abraham is that his descendants will be as numerous as the dust of the earth, promising abundance rather than the barrenness implied in Isaiah 49:21.
Genesis 13:16: And I will make thy seed as the dust of the earth: so that if a man can number the dust of the earth, [then] shall thy seed also be numbered.
Contradiction with Psalm 127:3-5
This verse highlights children as a heritage and reward from God, a blessing rather than a source of bewilderment and loneliness as expressed in Isaiah 49:21.
Psalm 127:3-5: Lo, children [are] an heritage of the LORD: [and] the fruit of the womb [is his] reward.
Contradiction with Jeremiah 29:6
Encourages the growth of families through marriage and childbirth, in contrast to the feeling of desolation and barrenness suggested in Isaiah 49:21.
Jeremiah 29:6: Take ye wives, and beget sons and daughters; and take wives for your sons, and give your daughters to husbands, that they may bear sons and daughters; that ye may be increased there, and not diminished.
Contradiction with Ezekiel 36:37-38
Speaks of multiplying the people like a flock, suggesting prosperity and increase contrary to the shock and barrenness in Isaiah 49:21.
Ezekiel 36:37-38: Thus saith the Lord GOD; I will yet [for] this be enquired of by the house of Israel, to do [it] for them; I will increase them with men like a flock.
Contradiction with Zechariah 8:4-5
Describes a vision of children playing in the streets of a prosperous Jerusalem, opposing the deserted, childless imagery in Isaiah 49:21.
Zechariah 8:4-5: Thus saith the LORD of hosts; There shall yet old men and old women dwell in the streets of Jerusalem, and every man with his staff in his hand for very age. [very...: Heb. multitude of days]