Contradiction with John 7:5
This verse mentions that even Jesus' own brothers did not believe in Him, which contrasts with the implication in Matthew 13:56 of Jesus' familial support.
John 7:5: For neither did his brethren believe in him.
Contradiction with Mark 3:21
Here, Jesus' family thinks He is out of His mind, which contradicts the notion of a supportive or understanding family in Matthew 13:56.
Mark 3:21: And when his friends heard [of it], they went out to lay hold on him: for they said, He is beside himself. [friends: or, kinsmen]
Contradiction with John 19:27
Jesus entrusts His mother to the disciple John, implying a shift or lack of support from His own family, in contrast to the familial presence in Matthew 13:56.
John 19:27: Then saith he to the disciple, Behold thy mother! And from that hour that disciple took her unto his own [home].