Contradiction with Luke 23:46
It states that Jesus, calling out with a loud voice, commended his spirit to the Father before he expired, implying he spoke words different from what is listed in Matthew 27:50.
Luke 23:46: And when Jesus had cried with a loud voice, he said, Father, into thy hands I commend my spirit: and having said thus, he gave up the ghost.
Contradiction with John 19:30
This verse states that Jesus' last words were "It is finished" before he bowed his head and gave up the ghost, which differs from the account in Matthew 27:50.
John 19:30: When Jesus therefore had received the vinegar, he said, It is finished: and he bowed his head, and gave up the ghost.
Contradiction with Mark 15:37
Indicates that Jesus made a loud cry before giving up the ghost, which could imply a different final utterance than that recorded in Matthew 27:50.
Mark 15:37: And Jesus cried with a loud voice, and gave up the ghost.